Applications

Biomedical Engineering

Cell sorting: Fabrication of bowl-shaped microholes with precise diameters (10–30 μm) enables size-based separation of tumor cells (50–100 μm) from normal cells (5–40 μm), featuring smooth edges to minimize cellular damage.

Cell adhesion/proliferation studies: Etching of 30×30 μm microstructures with 7±1 μm depth on biocompatible metals (e.g., platinum-iridium alloys) creates surfaces for observing cellular behavior, including adhesion, differentiation, and migration.

Sensor Fabrication

Strain-gauge sensors:  Production of microstructures with 6 μm minimum rib width (±0.5 μm precision) and<2 μm taper, converting mechanical loads (stress, torque, etc.) into the nanoampere (nA) level electrical signals for real-time state monitoring.

Advantages

· High-precision machining: Achieves micron/submicron-level control over feature dimensions (e.g., hole diameter, rib width), critical for reproducible experimental results.

· Athermal processing: Ultra-short pulses (10⁻¹⁵ seconds) eliminate thermal damage, preserving material properties and cellular viability in biometric applications.

· Material versatility: Processes metals (platinum, stainless steel), ceramics, and polymers without compromising structural integrity or biocompatibility.

· Micro-nano structure capability: Enables fabrication of complex geometries (bowl-shaped holes, micropattern arrays) for advanced research in cell biology, material science, and sensor engineering.